PERAN TIKUS DALAM PENELITIAN BIOMEDIS MANUSIA MINI DI DUNIA SAINS
Keywords:
laboratory mice, biomedical research, genetic manipulation, research ethics, animal models, medical translation.
Abstract
Mice are widely used in biomedical research due to their genetic similarity to humans, sharing 95–98% of genes. This study evaluates the benefits and challenges of using mice as laboratory models, focusing on genetic manipulation and ethical concerns. A review of recent scientific literature was conducted. Results show significant contributions to disease understanding and therapy development, but also highlight translational limitations and animal welfare issues. Emerging alternatives like computer models and organ-on-a-chip show potential. More ethical and sustainable approaches are needed for the future of biomedical research.
References
Perlman, R. L. (2016). Mouse models of human disease: An evolutionary perspective. Evolution, Medicine, and Public Health, 2016(1), 170–176.
Rosenthal, N., & Brown, S. (2007). The mouse ascending: perspectives for human-disease models. Nature Cell Biology, 9(9), 993–999.
Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S., ... & Worley, K. C. (2004). Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428(6982), 493–521.
Sharpless, N. E., & DePinho, R. A. (2006). The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Reviews Drug Discovery, 5(9), 741–754. https://doi.org/10.1038/nrd2110
Ashe, K. H., & Zahs, K. R. (2010). Probing the biology of Alzheimer’s disease in mice. Neuron, 66(5), 631–645.
National Institutes of Health (NIH). (2021). Animal Research Models: Rodents. Retrieved from
Beauchamp, T. L. (2001). In defense of the use of animals in biomedical research. Journal of Medical Ethics, 27(3), 191-193.
Hackam, D. G., & Redelmeier, D. A. (2006). Translation of research evidence from animals to humans. Journal of the American Medical Association (JAMA), 296(14), 1731–1732.
Zimmermann, M. (2009). Ethical aspects of animal research. In: Animal Experimentation: A Guide to the Issues. Macmillan.
Carbone, L., & Newberry, R. C. (2015). Environmental enrichment and laboratory animal welfare. In: Laboratory Animal Welfare. Springer.
Olsson, I. A. S. (2013). Environmental enrichment in laboratory animals: Principles and practices. Animal Welfare, 22(1), 33–40.
Benato, L., et al. (2016). Alternatives to animal testing in biomedical research: Emerging approaches and future perspectives. Biology Open, 5(12), 1922–1930.
Creswell, J. W. (2014). Research Design: Qualitative, Quantitative, and Mixed Methods Approaches (4th ed.). Thousand Oaks, CA: Sage Publications.
Moleong, L. J. (2017). Metodologi Penelitian Kualitatif (Edisi Revisi). Bandung: PT Remaja Rosdakarya.
Intan, P. R., & Khariri. (2020). Pemanfaatan Hewan Laboratorium Yang Sesuai untuk Pengujian Obat dan Vaksin. journal uin alauddin, 5(1), 48-53.
Miftahurahma, N. M. L., Andriyanto, Manalu, W., & Ilyas, A. Z. (2023). Efektivitas Minyak Kemiri (Aleurites moluccana L.) sebagai Penumbuh Rambut pada Tikus (Rattus norvegicus). Jurnal Veteriner dan Biomedis, 1(2), 65-71.
Nurmawati, T. (2017). STUDI RESPON FISIOLOGIS DAN KADAR GULA DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) YANG TERPAPAR STREPTOZOTOCIN (STZ). Jurnal Ners dan Kebidan, 4(3), 244-247.
Sihombing, M., & Tuminah, S. (2011). Perubahan Nilai Hematologi, Biokimia Darah, Bobot Organ dan Bobot Badan Tikus Putih pada Umur Berbeda. Jurnal Veteriner, 12(1), 58-64.
Rosenthal, N., & Brown, S. (2007). The mouse ascending: perspectives for human-disease models. Nature Cell Biology, 9(9), 993–999.
Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S., ... & Worley, K. C. (2004). Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428(6982), 493–521.
Sharpless, N. E., & DePinho, R. A. (2006). The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Reviews Drug Discovery, 5(9), 741–754. https://doi.org/10.1038/nrd2110
Ashe, K. H., & Zahs, K. R. (2010). Probing the biology of Alzheimer’s disease in mice. Neuron, 66(5), 631–645.
National Institutes of Health (NIH). (2021). Animal Research Models: Rodents. Retrieved from
Beauchamp, T. L. (2001). In defense of the use of animals in biomedical research. Journal of Medical Ethics, 27(3), 191-193.
Hackam, D. G., & Redelmeier, D. A. (2006). Translation of research evidence from animals to humans. Journal of the American Medical Association (JAMA), 296(14), 1731–1732.
Zimmermann, M. (2009). Ethical aspects of animal research. In: Animal Experimentation: A Guide to the Issues. Macmillan.
Carbone, L., & Newberry, R. C. (2015). Environmental enrichment and laboratory animal welfare. In: Laboratory Animal Welfare. Springer.
Olsson, I. A. S. (2013). Environmental enrichment in laboratory animals: Principles and practices. Animal Welfare, 22(1), 33–40.
Benato, L., et al. (2016). Alternatives to animal testing in biomedical research: Emerging approaches and future perspectives. Biology Open, 5(12), 1922–1930.
Creswell, J. W. (2014). Research Design: Qualitative, Quantitative, and Mixed Methods Approaches (4th ed.). Thousand Oaks, CA: Sage Publications.
Moleong, L. J. (2017). Metodologi Penelitian Kualitatif (Edisi Revisi). Bandung: PT Remaja Rosdakarya.
Intan, P. R., & Khariri. (2020). Pemanfaatan Hewan Laboratorium Yang Sesuai untuk Pengujian Obat dan Vaksin. journal uin alauddin, 5(1), 48-53.
Miftahurahma, N. M. L., Andriyanto, Manalu, W., & Ilyas, A. Z. (2023). Efektivitas Minyak Kemiri (Aleurites moluccana L.) sebagai Penumbuh Rambut pada Tikus (Rattus norvegicus). Jurnal Veteriner dan Biomedis, 1(2), 65-71.
Nurmawati, T. (2017). STUDI RESPON FISIOLOGIS DAN KADAR GULA DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) YANG TERPAPAR STREPTOZOTOCIN (STZ). Jurnal Ners dan Kebidan, 4(3), 244-247.
Sihombing, M., & Tuminah, S. (2011). Perubahan Nilai Hematologi, Biokimia Darah, Bobot Organ dan Bobot Badan Tikus Putih pada Umur Berbeda. Jurnal Veteriner, 12(1), 58-64.
Published
2025-06-16
How to Cite
Sabilla Azahra, D., Aulia Rahma, N., Amalia Aunillah, S., Hotijah, S., & Zulfadewina. (2025). PERAN TIKUS DALAM PENELITIAN BIOMEDIS MANUSIA MINI DI DUNIA SAINS. Didaktik : Jurnal Ilmiah PGSD STKIP Subang, 11(02), 453 - 466. https://doi.org/10.36989/didaktik.v11i02.5995
Section
Articles
